Inositol and Selenium Improve Hashimoto’s Disease

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I am always keeping up with the latest research on Hashimoto’s disease so I can stay on the cutting-edge and help patients get better as quickly and effectively as possible. We have some great news out of Italy recently that showed inositol and selenium had some major benefits in those with Hashimoto’s disease and subclinical hypothyroidism.

Can inositol help Hashimoto's disease?

This study was published in the European Review for Medical and Pharmacological Sciences entitled “Myo-inositol plus selenium supplementation restores euthyroid state in Hashimoto’s patients with subclinical hypothyroidism.”

This is a free paper so anyone can download it to read all of the details but I’ll break it down for you into simple terms.

168 patients ages 22 to 62 years had a TSH level between 3-6 mIU/L, elevated TPO and/or thyroglobulin antibodies, and normal free T4 and T3 levels. They were randomized into two groups and were given either 83 mcg of selenium or a combination of 600 mg of myo-inositol and 83 mcg of selenium for six months.

After six months of taking these supplements, all participants taking myo-inositol and selenium showed improvements in their TSH, Free T4, thyroid peroxidase antibody (TPO), and thyroglobulin antibody (TgAb). The group only taking selenium had a decrease in TPO levels which we have known for a while now based on previous research. Thyroglobulin levels however only decreased in the inositol+selenium group.

Additionally, subjects filled out a symptom questionnaire before and after which showed significant improvement in their thyroid-related symptoms.

What is Inositol?

I have written previously about selenium and Hashimoto’s disease but I haven’t covered inositol before. Some of you may wonder if myo-inositol and inositol are the same thing and the answer is yes. So if you buy a product that is just called “inositol”, this is the myo-inositol form. D-chiro-inositol is another form that works equally as well as myo-inositol, but the d-chiro-inositol has slight edge in reducing excessive androgen levels in PCOS whereas the myo form is better with insulin resistance.

I have mainly used inositol over the years with excellent results for the following:

Polycystic ovarian syndrome (PCOS)
Insomnia
Anxiety
Insulin resistance
PMS
Depression
Fibrocystic breast disease
Uterine fibroids

What is the best way to take inositol?

This study used 600 mg/day taken on an empty stomach. The authors state to take “2 hours before or after the meal.” My recommendations for empty stomach are at least 30 minutes before a meal or at least 2 hours after.

A lot of inositol products come in 900-1,000 mg capsules and I don’t think it is a problem to get some extra inositol, but be sure to consult your doctor about supplementation doses. Inositol powder supplements are also available to be more precise in dosing. I actually like the taste of the powder which has a mild sweet taste so it goes down easily.

Inositol appears to be a real “heavy hitter” in Hashimoto’s disease and subclinical hypothyroidism so I have added it to my protocol for patients. Inositol may also provide you some relief from some of the symptoms I noted above that overlap with thyroid disorders.

As always, I’ll keep you updated on the latest research in Hashimoto’s disease and thyroid disorders.

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