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One of the most common questions I get is, “What are optimal Hashimoto’s thyroiditis antibody levels?” For years, many patients and clinicians have been chasing thyroid peroxidase (TPO) and anti-thyroglobulin (TG) antibody levels in an attempt to get them as low as possible or even undectable as a measure of success. This can leave many people frustrated and stressed about their condition. Some individuals feel that these levels should become undetectable in order to consider the condition in complete remission. But is this entirely true or necessary?