There have never been any studies on leaky gut and Hashimoto’s disease but now we have a new study on this connection. Leaky gut was something rejected by conventional medicine despite the fact that papers on leaky gut date back to the 1970s. For many years functional medicine practitioners have been testing for it and treating it which has helped many patients overcome their chronic illnesses. There are currently over 500 published scientific papers on leaky gut so there is no doubt it exists.
There is a new exciting paper on the connection between eradicating the intestinal parasite Blasctocystis hominis and improving Hashimoto’s disease. I previously reported this infection connection in a case study which revealed an individual with Hashimoto’s disease getting better after eradicating Blastocystis hominis. Case studies aren’t the strongest scientific proof of a particular therapy but now we have an excellent paper with three research groups including a much-needed control group.
Human herpesvirus 6 or HHV-6, is a herpes virus just like Epstein-Barr Virus, Cytomegalovirus, Chicken pox (varicella zoster), HHV-7, HHV-8 and Herpes simplex 1 and 2. There are two types of this virus including HHV-6A and HHV-6B. 100% of human beings get infected with HHV-6B by the age of three which results in fever, diarrhea and a rash called roseola. In rare cases it can cause seizures and encephalitis. There are many infection connections to autoimmune diseases like Hashimoto’s disease and in this article I’ll cover the connection between HHV-6 and Hashimoto’s disease.
The connection between iodine and Hashimoto’s disease has been one of the most requested topics that I cover, so I’d like to present the research on this topic, so we can set the record straight. Please be aware that none of this is my opinion but rather a detailed analysis of what the scientific literature currently presents.
Your body has about 15 to 20 mg of iodine and 70 to 80% of it resides in the thyroid gland. Iodine is transported into the thyroid gland through the sodium-iodine symporter or NIS. The thyroid peroxidase enzyme oxidizes iodine which is then integrated into thyroglobulin resulting in the production of thyroxine (T4) and triiodothyronine (T3). Thyroid stimulating hormone (TSH) regulates this process.
Your thyroid only needs 150 to 250 micrograms a day of iodine to function properly. Once iodine intake exceeds this range, hypothyroidism and autoimmune thyroid disease may occur in some individuals.
“All disease begins in the gut.” –Hippocrates
Was Hippocrates right over 2,000 years ago? I would have to agree with him a majority of the time when it comes to chronic diseases. A healthy digestive system begins with excellent digestion so let’s go over some tips to help you improve your digestion naturally. Firstly, I’d like to briefly cover the reason why your digestion may be out of balance.
What causes bad digestion?
Eating very quickly while on the run and not completely focusing on your meal will result in poor digestion. You must be in a parasympathetic dominant state which is your “rest and digest” branch of your nervous system. Many people are sympathetic dominant when they eat which is the “fight or flight” branch of your nervous system.
Inflammation is at the core of most chronic illnesses including hypothyroidism and Hashimoto’s disease. But how exactly does inflammation cause hypothyroidism? Nonthyroidal illness syndrome (NTIS) is the state in which inflammation causes negative changes to thyroid hormone including low T3 and increased reverse T3 (rT3). T3 is the most active form of thyroid hormone and rT3 actually blocks T3 receptors so inflammation can really knock out thyroid function. TSH levels however stay relatively “normal” in NTIS thus leaving many patients with the symptoms of hypothyroidism but no diagnosis since no one is checking their T3 or rT3 levels.
In this article I’ll be referencing a paper entitled, “IL-6 promotes nonthyroidal illness syndrome by blocking thyroxine activation while promoting thyroid hormone inactivation in human cells.”
TSH is the current gold standard for diagnosis of hypothyroidism but are the current TSH levels optimal and how do they relate to Hashimoto’s disease? An excellent paper out of China entitled, “Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort” has shed some light on this important question which looked at the upper limit of TSH levels in relation to Hashimoto’s disease and hypothyroidism.
The authors begin by stating that subclinical hypothyroidism is characterized by “normal” T4, T3, Free T4, and Free T3 with an elevated TSH. And these patients have an increased risk of cholesterol abnormalities, heart disease, mental illness, and pregnancy complications even though their symptoms are relatively mild.
Your gut microbiota has an intimate connection with your thyroid including connections with hypothyroidism, Hashimoto’s disease and Graves’ disease. In this research review I’d like to cover a recent paper entitled, “Microbiota and Thyroid Interaction in Health and Disease” published in the journal Trends in Endocrinology and Metabolism by Eleonare Frohlich and Richard Wahl.
The authors begin by stating that the gut microbiota can act on thyroid function due to the region of where someones lives, their diet including iodine intake, obesity, age, sex hormones, and how autoimmunity can impact the microbiota. I was impressed to see them state that the gut microbiota is linked to autoimmune disease, estrogen, iodine, and obesity. Estrogen can be a key factor in Hashimoto’s disease and a healthy gut is required for optimal estrogen metabolism and excretion through the feces.
They also mention the connection between the gut and the liver in relation to thyroid hormone metabolism in both these organ systems. Your gut is key to properly absorbing and utilizing the thyroid medication that you’re taking and they mention this as well.
Ashwagandha is one of my favorite supplements for Hashimoto’s disease and hypothyroidism and we have some excellent studies to support using it for these conditions.
The main study I’ll cover in this research review is entitled, “Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial” published in The Journal of Alternative and Complementary Medicine. We’re already off to a good start just by reading the title which indicates that it is a double-blind, randomized placebo-controlled study so we know it is of the highest standard.
We finally have a study specifically looking at the efficacy of the Autoimmune Protocol Diet, also known as the Autoimmune Paleo Diet or AIP, and Hashimoto’s disease. The exact title of the paper is, “Efficacy of the Autoimmune Protocol Diet as Part of a Multi-disciplinary, Supported Lifestyle Intervention for Hashimoto’s Thyroiditis” by Abbott et al. Published in April of 2019 in the journal Cureus. I break down the study details below so you can better understand if this diet actually works for Hashimoto’s disease.