Does the liver affect thyroid health? I’ll try to answer this question in detail throughout this article. The liver is an extremely complex organ involved in multiple immune and metabolic processes. If the liver is not detoxifying optimally, it will be virtually impossible to have success with any disease including thyroid and hormone imbalances. Unfortunately, many patients are given hormones without a thorough analysis of their liver’s ability to metabolize hormones. This can do more harm than good due to a build-up of unmetabolized hormones or incompletely metabolized hormones circulating in the blood- stream causing abnormal hormone responses. Partially metabolized hormones can bind to hormone receptor sites blocking normal hormones from binding and causing abnormal responses.