mast cell activation syndrome

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Histamine is often overlooked as a cause of chronic health problems yet the fix for this issue can be quite straightforward. In this article, I cover the details of histamine and how to follow a low histamine diet.

Histamine intolerance (HIT) affects approximately 1% of the population. Approximately 80% of those affected are middle-aged.1 Histamine intolerance occurs when an individual has more histamine in their system than they can breakdown. Excess systemic concentrations of histamine can result from overproduction, overconsumption, and/or having a reduced ability to clear out histamine from the body. For those with HIT, eating a diet that results in increased histamine can contribute to chronic inflammation due to the ongoing exposure to histamine. This excess histamine often accumulates as a result of decreased diamine oxidase (DAO) activity.2, 3 The resulting excess histamine contributes to the physical symptoms associated with HIT. Following a low-histamine diet along with supplemental DAO is often recommended to decrease the symptoms associated with HIT. Eating a low-histamine diet involves more than simply eliminating foods that are high in histamine. This article will help to explain the challenges with following a low histamine diet and will highlight the many ways excess histamine can occur in food and in the body.

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In this episode of Functional Medicine Research, I interview Dr. Bruce Hoffman, who’s a board certified physician and he has a fellowship in Anti-Aging as well as a Master’s degree in Clinical Nutrition. He is also a certified functional medicine practitioner. Speaking with Dr. Hoffman was extremely educational, we spoke about mast cell activation syndrome and how exactly the condition is diagnosed. Dr. Hoffman covers how he first got interested in the disease and the progress that he’s made working with several other doctors working to understand the implications of mast cell activation syndrome. Dr. Hoffman explains how some conditions overlap and indicate mast cell activation syndrome; such as fatigue, brain fog, and even GERD. You should come away from this interview with a much better understanding of mast cell activation syndrome, how it’s diagnosed and what lab tests are beneficial in assisting in this diagnosis.

How to Follow a Low Histamine Diet

Mast Cell Activation Syndrome with Dr. Bruce Hoffman

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